OXSR1

From Wikipedia, the free encyclopedia

Oxidative-stress responsive 1

Identifiers

OXSR1; KIAA1101; OSR1

External IDs

OMIM: 604046 MGI: 1917378 HomoloGene: 31288

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • response to oxidative stress • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005109 (mRNA)
NP_005100 (protein)

XM_135264 (mRNA)
XP_135264 (protein)

Location

Chr 3: 38.18 - 38.27 Mb

Chr 9: 119.09 - 119.17 Mb

Pubmed search

[1]

[2]

Oxidative-stress responsive 1, also known as OXSR1, is a human gene.^[1]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.^[1]

[edit] References

^ ^a ^b Entrez Gene: OXSR1 oxidative-stress responsive 1.

[edit] Further reading

Tamari M, Daigo Y, Nakamura Y (1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.". J. Hum. Genet. 44 (2): 116–20. PMID 10083736.
Daigo Y, Isomura M, Nishiwaki T, et al. (1999). "Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.". DNA Res. 6 (1): 37–44. PMID 10231028.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.
Piechotta K, Lu J, Delpire E (2003). "Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).". J. Biol. Chem. 277 (52): 50812–9. doi:10.1074/jbc.M208108200. PMID 12386165.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen W, Yazicioglu M, Cobb MH (2004). "Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.". J. Biol. Chem. 279 (12): 11129–36. doi:10.1074/jbc.M313562200. PMID 14707132.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
Cusick JK, Xu LG, Bin LH, et al. (2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.". Biochem. Biophys. Res. Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMID 16669787.
Anselmo AN, Earnest S, Chen W, et al. (2006). "WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (29): 10883–8. doi:10.1073/pnas.0604607103. PMID 16832045.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Villa F, Goebel J, Rafiqi FH, et al. (2007). "Structural insights into the recognition of substrates and activators by the OSR1 kinase.". EMBO Rep. 8 (9): 839–45. doi:10.1038/sj.embor.7401048. PMID 17721439.