Talk:Oxidative stress

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Contents 1 Body's Natural Defences 2 A few suggestions 3 In relation to Alzheimer's Disease and the Tocopherol article 4 Question about oxidative stress on the subject of weight loss and fitness program

[edit] Body's Natural Defences

The article has talked about NADPH but it says nothing about the main way in which NADPH is produced (i.e. the Pentose Phosphate Pathway). I believe there are another two pathways that are also used by the body to enhance the its reducing capabilities. Maybe this should be another section in the article? —Preceding unsigned comment added by 59.101.89.179 (talk) 08:36, 2 June 2008 (UTC)

[edit] A few suggestions

Hi Tim,

Nice work! It's not my area, but I was caught a little off-guard by the lead statement

The cellular redox environment is preserved by enzymes...

I guess I would lay more emphasis on the glutathione concentration

The cellular reducing environment results from a high concentration of glutathione (5 mM), which is preserved by enzymes...

and maybe talk about things that affect that concentration, such as fasting (if I recall correctly)? Oh, and wasn't there a nifty crosslinked version, trypanothione? But I hear that it's found only in a few inconsequential organisms. ;D

I also kind of missed thioredoxin and glutaredoxin; should they be mentioned here?

Some discussion of the SS bond formation in the ER might be nice, too. Good luck and talk to you soon, Willow 00:00, 7 January 2007 (UTC)

Hi Willow

I'm hoping to expand the Antioxidant page to deal with the biological antioxidants in a more rigorous way, so the various whateveredoxins can go there, along with a discussion of glutathione, ascorbate etc. It is correct to say that enzymes maintain the intracellular redox state, since they link the GSH/GSSG redox couple with the NADPH/NADP redox couple and maintain the glutathione in its reduced thiol form. Synthesis of new GSH might contribute a little to this process, but the majority is glutathione reductase recycling the glutathione disulphide that's produced as GSH reacts with by oxidants. Maybe I need to make this more clear. TimVickers 00:23, 7 January 2007 (UTC)

Oh, I didn't mean to suggest that the enzymes weren't ultimately responsible for maintaining the redox state. I was only worried that some people might imagine that the enzymes themselves were running around the cell reducing everything, instead of acting indirectly through the glutathione couple. I'll be interested in the antioxidant page; I'm sure that a lot of people will be interested in it. Good luck Willow 00:51, 7 January 2007 (UTC)

I'm totally embarrassed that I mentioned trypanothione to you, when you did your thesis on it! I knew that you had worked on T. cruzi (hence the "inconsequential" joke above) but I hadn't stopped to study the titles of your journal articles — oops! Depending on your kind indulgence for my dimness and preemptive congratulations on becoming an admin, Willow 18:21, 23 February 2007 (UTC)

[edit] In relation to Alzheimer's Disease and the Tocopherol article

Opinions of the effect of Vitamin E on the prevention of Alzheimer's Disease differ in this and the Tocopherol article. -- Squater 27 June 2007

I've rewritten that part of the tocopherol article. Tim Vickers (talk) 19:17, 2 May 2008 (UTC)

[edit] Question about oxidative stress on the subject of weight loss and fitness program

An informative internet article hinted to readers to

"Consider taking a CLA (Conjugated linoleic acid), 1000mg 3 times a day with meals. In studies CLA was shown to reduce body fat, in particular in the belly area. If you have diabetes or are at risk for diabetes, check with your doctor first."

When I read about CLA on wikipedia, it explained that this would induce oxidative stress within the human body. My question is will this do damage to the body as a whole in anyway; reducing our lifespam any?

From my readings of the wikipedia information available to me; the conclusion I came to was that it may or may not result in the human lifespan becoming a bit shorter.

I wanted to confirm its safety become considering it as a dietary supplement.

Michael Nguyen mknguyen@gmail.com —Preceding unsigned comment added by 24.175.253.209 (talk) 18:33, 2 May 2008 (UTC)