Oxalyl-CoA decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, an oxalyl-CoA decarboxylase (EC 4.1.1.8) is an enzyme that catalyzes the chemical reaction

oxalyl-CoA formyl-CoA + CO₂

Hence, this enzyme has one substrate, oxalyl-CoA, and two products, formyl-CoA and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is oxalyl-CoA carboxy-lyase (formyl-CoA-forming). Other names in common use include oxalyl coenzyme A decarboxylase, and oxalyl-CoA carboxy-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2C31, 2JI6, 2JI7, 2JI8, 2JI9, and 2JIB.

[edit] References

• IUBMB entry for 4.1.1.8
• BRENDA references for 4.1.1.8 (Recommended.)
• PubMed references for 4.1.1.8
• PubMed Central references for 4.1.1.8
• Google Scholar references for 4.1.1.8
• Quayle JR (1963). "Carbon assimilation by Pseudomonas oxalaticus (OX1). 7 Decarboxylation of oxalyl-coenzyme A to formyl-coenzyme A". Biochem. J. 89: 492–503. 

[edit] External links

The CAS registry number for this enzyme class is 9024-96-8.

• IUBMB entry for 4.1.1.8

• KEGG entry for 4.1.1.8

• BRENDA entry for 4.1.1.8

• NiceZyme view of 4.1.1.8

• EC2PDB: PDB structures for 4.1.1.8

• PRIAM entry for 4.1.1.8

• PUMA2 entry for 4.1.1.8

• IntEnz: Integrated Enzyme entry for 4.1.1.8

• MetaCyc entry for 4.1.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008949: oxalyl-CoA decarboxylase

• AMIGO entry for GO code 0008949: oxalyl-CoA decarboxylase