OVGP1

From Wikipedia, the free encyclopedia

Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)

Identifiers

OVGP1; EGP; CHIT5; MUC9; OGP

External IDs

OMIM: 603578 MGI: 106661 HomoloGene: 74442

Gene ontology
Molecular Function:	• catalytic activity • chitinase activity • cation binding
Cellular Component:	• extracellular space
Biological Process:	• carbohydrate metabolic process • chitin catabolic process • single fertilization • female pregnancy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002557 (mRNA)
NP_002548 (protein)

NM_007696 (mRNA)
NP_031722 (protein)

Location

Chr 1: 111.76 - 111.77 Mb

Chr 3: 106.1 - 106.12 Mb

Pubmed search

[1]

[2]

Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin), also known as OVGP1, is a human gene.^[1]

This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.^[1]

[edit] References

^ ^a ^b Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin).

[edit] Further reading

Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct.". Endocrinology 122 (4): 1639–45. PMID 3278893.
Arias EB, Verhage HG, Jaffe RC (1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein.". Biol. Reprod. 51 (4): 685–94. PMID 7819450.
Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins.". J. Dent. Res. 76 (3): 734–43. PMID 9109822.
Lapensée L, Paquette Y, Bleau G (1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9).". Fertil. Steril. 68 (4): 702–8. PMID 9341614.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.". J. Dent. Res. 79 (2): 732–9. PMID 10728974.
Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter.". Mol. Hum. Reprod. 8 (2): 167–75. PMID 11818519.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle.". J. Assist. Reprod. Genet. 19 (12): 569–76. PMID 12503889.
Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein.". Hereditas 139 (1): 75–9. PMID 14641477.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Woo MM, Alkushi A, Verhage HG, et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer.". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.
Ling L, Lee YL, Lee KF, et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line.". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.
Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9.". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.