OS9 (gene)

From Wikipedia, the free encyclopedia


Amplified in osteosarcoma
Identifiers
Symbol(s) OS9;
External IDs OMIM: 609677 MGI: 1924301 HomoloGene: 31409
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10956 216440
Ensembl ENSG00000135506 ENSMUSG00000040462
Uniprot Q13438 n/a
Refseq NM_001017956 (mRNA)
NP_001017956 (protein)		 NM_177614 (mRNA)
NP_808282 (protein)
Location Chr 12: 56.37 - 56.4 Mb Chr 10: 126.5 - 126.52 Mb
Pubmed search [1] [2]

Amplified in osteosarcoma, also known as OS9, is a human gene.[1]

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: OS9 amplified in osteosarcoma.

[edit] Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Baek JH, Mahon PC, Oh J, et al. (2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.". Mol. Cell 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Vigneron N, Ooms A, Morel S, et al. (2003). "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma.". Cancer Immun. 2: 9. PMID 12747754. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Litovchick L, Friedmann E, Shaltiel S (2002). "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta.". J. Biol. Chem. 277 (37): 34413–23. doi:10.1074/jbc.M203986200. PMID 12093806. 
  • Friedmann E, Salzberg Y, Weinberger A, et al. (2002). "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins.". J. Biol. Chem. 277 (38): 35274–81. doi:10.1074/jbc.M201044200. PMID 12077121. 
  • Nakayama T, Yaoi T, Kuwajima G, et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma.". FEBS Lett. 453 (1-2): 77–80. PMID 10403379. 
  • Kimura Y, Nakazawa M, Yamada M (1998). "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines.". J. Biochem. 123 (5): 876–82. PMID 9562620. 
  • Kimura Y, Nakazawa M, Tsuchiya N, et al. (1998). "Genomic organization of the OS-9 gene amplified in human sarcomas.". J. Biochem. 122 (6): 1190–5. PMID 9498564. 
  • Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.". Genomics 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850. 
  • Su YA, Hutter CM, Trent JM, Meltzer PS (1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas.". Mol. Carcinog. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.