ORC5L

From Wikipedia, the free encyclopedia

Origin recognition complex, subunit 5-like (yeast)

Identifiers

ORC5L; ORC5; ORC5P; ORC5T

External IDs

OMIM: 602331 MGI: 1347044 HomoloGene: 37636

Gene ontology
Molecular Function:	• nucleotide binding • molecular_function • DNA replication origin binding • ATP binding • identical protein binding
Cellular Component:	• nucleus • nuclear origin of replication recognition complex
Biological Process:	• DNA replication • DNA replication initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002553 (mRNA)
NP_002544 (protein)

NM_011959 (mRNA)
NP_036089 (protein)

Location

Chr 7: 103.55 - 103.64 Mb

Chr 5: 22 - 22.06 Mb

Pubmed search

[1]

[2]

Origin recognition complex, subunit 5-like (yeast), also known as ORC5L, is a human gene.^[1]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Klemm RD, Austin RJ, Bell SP (1997). "Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.". Cell 88 (4): 493-502. PMID 9038340.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Ishiai M, Dean FB, Okumura K, et al. (1998). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22.". Genomics 46 (2): 294-8. doi:10.1006/geno.1997.5003. PMID 9417919.
Quintana DG, Thome KC, Hou ZH, et al. (1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.". J. Biol. Chem. 273 (42): 27137-45. PMID 9765232.
Tugal T, Zou-Yang XH, Gavin K, et al. (1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.". J. Biol. Chem. 273 (49): 32421-9. PMID 9829972.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.". EMBO J. 18 (20): 5703-13. doi:10.1093/emboj/18.20.5703. PMID 10523313.
Thome KC, Dhar SK, Quintana DG, et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.". J. Biol. Chem. 275 (45): 35233-41. doi:10.1074/jbc.M005765200. PMID 10954718.
Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex.". J. Biol. Chem. 276 (28): 26666-73. doi:10.1074/jbc.M102493200. PMID 11323433.
Fröhling S, Nakabayashi K, Scherer SW, et al. (2001). "Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.". Hum. Genet. 108 (4): 304-9. PMID 11379876.
Dhar SK, Delmolino L, Dutta A (2001). "Architecture of the human origin recognition complex.". J. Biol. Chem. 276 (31): 29067-71. doi:10.1074/jbc.M103078200. PMID 11395502.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111-28. PMID 12614612.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86-90. doi:10.1126/science.1097639. PMID 15232106.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.