Talk:Opioid receptor
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This article may be too technical for a general audience. Please help improve this article by providing more context and better explanations of technical details to make it more accessible, without removing technical details. |
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[edit] Symbols
Should this article really be using Greek symbols without a name? i.e. Mu, Delta, etc.? --Wulf 23:53, 28 February 2006 (UTC)
seriously you pretentious asswipes you should use the "mu" "kappa" and "delta" labeling for a less complicated search —Preceding unsigned comment added by 155.33.153.140 (talk • contribs)
I agree the Greek symbols should be glossed with their spelled-out forms. Dforest 17:16, 5 March 2006 (UTC) Ah. I see now they are already spelled out in "Types of receptors". Perhaps they should be linked as well? It seems I am not the only one to overlook them. Dforest 17:21, 5 March 2006 (UTC)
Greek lettering for the receptor types has nothing to do with being a "pretentious asswipe". but is in fact the correct way to denote the receptors. If you don't understand the Greek lettering, that doesn't make anyone but you an asswipe. If you are reading about pharmacology, hopefully you should understand that much. —Preceding unsigned comment added by 66.213.109.42 (talk • contribs)
Well, I also think it's unnecessarily confusing. The receptors are referred to as spelled-out "mu" etc. at least as often as they are by the Greek letter. I've even seen an abstract where the mu receptors were referred to as "micro-opioid receptors". Took me a while to realize that someone had interpreted the letter mu as the metric prefix for micro- (or one millionth). But yes, I also missed the explanation in "types of receptors". I don't think it benefits the article at all to have the actual Greek letters used; it's not like it illuminates anything pharmacological. --Galaxiaad 20:44, 14 March 2007 (UTC)
[edit] sigma
since sigma recepters are activated by drugs unrealated to opiods shouldn't they recieve thier own page, rather than being part of the opiod recepter page.
[edit] Alkaloids
Under the mu receptor section, I amended the last sentence of the first paragraph. It listed Morphine, Hydrocodone, and Methadone as "opioid alkaloids". Morphine is an alkaloid. Hydrocodone and Methadone are not plant derived amines, so they aren't alkaloids. I inserted morphine and codeine in their place, as those are the only two plant derived opiate agonists. ~Drew 26 September 2006 15:26 (EST) (—Preceding unsigned comment added by 66.213.109.42 (talk • contribs) )
[edit] Sigma receptors are distinct from opiod receptors
Although sigma receptors were historically linked to the opioid receptor, modern science has shown that they are unrelated. A quick Google search will give ample references to justify separating them from opiod receptors. The distinction between sigma-1 and sigma-2 receptors is pharmacologically defined and they appear to have very different biological roles. Sigma-2 receptors are believed to play a role in proliferation, since they are over-expressed in many tumor cell lines. Some sigma- ligands show promise as a anti-cancer agents. Sigma-1 antagonists can show anti-depressant action. Even though the endogenous ligands for these receptors are unknown, sigma-1 has been sequenced and sigma-1 knockout mice have been generated. These receptors deserve their own article.TriLAJy 21:33, 21 November 2006 (UTC) TriLAJy
[edit] So what do the recepters do?
THe article explained what these recepters are and what they are called, but it never said how they are important. What do they do? —The preceding unsigned comment was added by 24.41.10.240 (talk) 20:10, 19 March 2007 (UTC).
you guys have the effects of mu1 and mu2 switched - now I don't know how to edit, so I'll leave that to you. its mu1 that causes euphoria, etc. it can be found on any basic pharma/neuro website —Preceding unsigned comment added by 75.85.68.248 (talk) 09:44, 22 December 2007 (UTC)
[edit] Could be simpler...
As a lay person, I have no idea what any part of this medical article means. Perhaps someone could add a simple summary previous to the article launching into technical details? --Pipedreambomb (talk) 00:28, 7 March 2008 (UTC)
