Talk:Open reading frame

From Wikipedia, the free encyclopedia

	This article is part of WikiProject Genetics, an attempt to build a comprehensive and detailed guide to genetics on Wikipedia. If you would like to participate, you can edit this page, or visit the project page to join the project and/or contribute to the discussion.
???	This article has not yet received a rating on the quality scale.
???	This article has not yet received an importance rating.

fixed the notion that there is difficulty in reading possible ORF's in eukaryotic mRNA. It is normally monocistronic, so usually only a single ORF is contained therefore looking for the longest possible gene sequence between a start and stop codon should give you the correct amino acid sequence. Active contributor 17:27, 20 March 2007 (UTC)

[edit] ORF without stop codon!?

The article claims that the "open" in ORF means that there is no stop codon. Surely this is incorrect! An ORF as far as I know extends from a start to a stop codon. So if in the example only one of the three frames has a stop codon then that one is the only ORF - right?

[1] which is even referenced in the article also says: "An open reading frame starts with an atg (Met) in most species and ends with a stop codon (taa, tag or tga)."

--203.109.144.209 23:11, 16 May 2007 (UTC)