OLR1

From Wikipedia, the free encyclopedia

Oxidized low density lipoprotein (lectin-like) receptor 1

PDB rendering based on 1ypo.

Available structures: 1ypo, 1ypq, 1ypu, 1yxj, 1yxk

Identifiers

Symbol(s)

OLR1; CLEC8A; LOX1; SCARE1

External IDs

OMIM: 602601 MGI: 1261434 HomoloGene: 1910

Gene ontology
Molecular Function:	• receptor activity • low-density lipoprotein receptor activity • protein binding • sugar binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• proteolysis • inflammatory response • immune response • cell adhesion • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002543 (mRNA)
NP_002534 (protein)

XM_984831 (mRNA)
XP_989925 (protein)

Location

Chr 12: 10.2 - 10.22 Mb

Chr 6: 129.45 - 129.47 Mb

Pubmed search

[1]

[2]

Oxidized low density lipoprotein (lectin-like) receptor 1, also known as OLR1, is a human gene.^[1] This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternative transcript variants have been described but their full-length sequence has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: OLR1 oxidized low density lipoprotein (lectin-like) receptor 1.

[edit] Further reading

Sawamura T (2002). "[Molecular identification of LOX-1 and analysis of its pathophysiological role]". Nippon Yakurigaku Zasshi 119 (3): 145–54. PMID 11915516.
Mehta JL, Li D (2002). "Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.". J. Am. Coll. Cardiol. 39 (9): 1429–35. PMID 11985903.
Sawamura T (2002). "[LOX-1: the oxidized LDL receptor expressed in vascular endothelial cells]". Seikagaku 74 (5): 365–76. PMID 12073608.
Ando K, Fujita T (2005). "Role of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the development of hypertensive organ damage.". Clin. Exp. Nephrol. 8 (3): 178–82. doi:10.1007/s10157-004-0288-9. PMID 15480893.
Sawamura T, Kume N, Aoyama T, et al. (1997). "An endothelial receptor for oxidized low-density lipoprotein.". Nature 386 (6620): 73–7. doi:10.1038/386073a0. PMID 9052782.
Yoshida H, Kondratenko N, Green S, et al. (1998). "Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor.". Biochem. J. 334 ( Pt 1): 9–13. PMID 9693095.
Mehta JL, Li DY (1998). "Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells.". Biochem. Biophys. Res. Commun. 248 (3): 511–4. doi:10.1006/bbrc.1998.9004. PMID 9703956.
Li X, Bouzyk MM, Wang X (1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene.". Cytogenet. Cell Genet. 82 (1-2): 34–6. PMID 9763655.
Yamanaka S, Zhang XY, Miura K, et al. (1999). "The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile.". Genomics 54 (2): 191–9. doi:10.1006/geno.1998.5561. PMID 9828121.
Nagase M, Abe J, Takahashi K, et al. (1999). "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene.". J. Biol. Chem. 273 (50): 33702–7. PMID 9837956.
Draude G, Hrboticky N, Lorenz RL (1999). "The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin.". Biochem. Pharmacol. 57 (4): 383–6. PMID 9933026.
Aoyama T, Sawamura T, Furutani Y, et al. (1999). "Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.". Biochem. J. 339 ( Pt 1): 177–84. PMID 10085242.
Li DY, Zhang YC, Philips MI, et al. (1999). "Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation.". Circ. Res. 84 (9): 1043–9. PMID 10325241.
Kataoka H, Kume N, Miyamoto S, et al. (1999). "Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.". Circulation 99 (24): 3110–7. PMID 10377073.
Li D, Saldeen T, Romeo F, Mehta JL (2000). "Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB.". Circulation 102 (16): 1970–6. PMID 11034947.
Bull C, Sobanov Y, Röhrdanz B, et al. (2001). "The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region.". Genes Immun. 1 (4): 280–7. doi:10.1038/sj.gene.6363678. PMID 11196705.
Shi X, Niimi S, Ohtani T, Machida S (2001). "Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor.". J. Cell. Sci. 114 (Pt 7): 1273–82. PMID 11256994.
Chen M, Narumiya S, Masaki T, Sawamura T (2001). "Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.". Biochem. J. 355 (Pt 2): 289–96. PMID 11284714.
Tanimoto A, Murata Y, Nomaguchi M, et al. (2001). "Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells.". FEBS Lett. 508 (3): 345–9. PMID 11728449.
Sobanov Y, Bernreiter A, Derdak S, et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex.". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369.