Talk:Oleamide
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It is definitly no terpene and is absolutly not related to Cannabinoids so we should change this.--Stone 15:15, 14 June 2007 (UTC)
- Oleamide can be considered a cannabinoid because the term is applied to any compound that interacts with the cannabinoid receptor, even if it is structurally unrelated to THC. See anandamide for another example.
Also sometimes the natural peptides that interact at the CB receptors are referred to as "endogenous cannabinoids".--Ed (Edgar181) 17:10, 14 June 2007 (UTC)- First of all there are no natural peptides that activate CB receptors. Secondly, the evidence is scant, at best, that Oleamide activates CB receptors and evidence that oleamide does NOT activate CB receptors is more voluminous and convincing, and third, oleamide could technically be considered 'related' to cannabinoids because it is broken down by FAAH which also terminates anandamide however it is not, itself, an endocannabinoid. The only two endogenous substances known to activate CB receptors are anandamide and 2-AG and I can find you a thousand papers to support that, if you like. There is some evidence that other polyunsaturated N-acyl ethanolamines (such as linoleoyl ethanolamide or docosahexaenoyl ethanolamide) may also be able to activate CB receptors weakly but this evidence is weak. Roadnottaken 18:13, 14 June 2007 (UTC)
- Sorry, I was thinking of another receptor when I wrote that statement about peptides. There is certainly report of cannabinoid agonism by oleamide, but I'm not familiar enough with the field to weigh conflicting evidence. Since this is your area of research, feel free to categorize oleamide and anandamide as a cannabinoid or not as you see fit. --Ed (Edgar181) 18:27, 14 June 2007 (UTC)
- No problem. The oleamide/CB connection is confusing and somewhat controversial but I'm adding another line in the text to explain it. Roadnottaken 18:49, 14 June 2007 (UTC)
- Thanks!! I look onto the topic from the chemistry side and there you simply you would never put something in a group which is labled terpenes which is a fatty acid derivate, but with a sentence about Cannabinoids like acting or having the same effect like Cannabinoids is the ideal solution.--Stone 07:14, 15 June 2007 (UTC)
- No problem. The oleamide/CB connection is confusing and somewhat controversial but I'm adding another line in the text to explain it. Roadnottaken 18:49, 14 June 2007 (UTC)
- Sorry, I was thinking of another receptor when I wrote that statement about peptides. There is certainly report of cannabinoid agonism by oleamide, but I'm not familiar enough with the field to weigh conflicting evidence. Since this is your area of research, feel free to categorize oleamide and anandamide as a cannabinoid or not as you see fit. --Ed (Edgar181) 18:27, 14 June 2007 (UTC)
- First of all there are no natural peptides that activate CB receptors. Secondly, the evidence is scant, at best, that Oleamide activates CB receptors and evidence that oleamide does NOT activate CB receptors is more voluminous and convincing, and third, oleamide could technically be considered 'related' to cannabinoids because it is broken down by FAAH which also terminates anandamide however it is not, itself, an endocannabinoid. The only two endogenous substances known to activate CB receptors are anandamide and 2-AG and I can find you a thousand papers to support that, if you like. There is some evidence that other polyunsaturated N-acyl ethanolamines (such as linoleoyl ethanolamide or docosahexaenoyl ethanolamide) may also be able to activate CB receptors weakly but this evidence is weak. Roadnottaken 18:13, 14 June 2007 (UTC)
