OASL

From Wikipedia, the free encyclopedia

2'-5'-oligoadenylate synthetase-like

PDB rendering based on 1wh3.

Available structures: 1wh3

Identifiers

Symbol(s)

OASL; TRIP14; p59OASL

External IDs

OMIM: 603281 MGI: 2180849 HomoloGene: 2769

Gene ontology
Molecular Function:	• DNA binding • double-stranded RNA binding • ATP binding • transferase activity • thyroid hormone receptor binding
Cellular Component:	• nucleolus • cytoplasm
Biological Process:	• protein modification process • immune response • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003733 (mRNA)
NP_003724 (protein)

NM_145209 (mRNA)
NP_660210 (protein)

Location

Chr 12: 119.94 - 119.96 Mb

Chr 5: 115.18 - 115.2 Mb

Pubmed search

[1]

[2]

2'-5'-oligoadenylate synthetase-like, also known as OASL, is a human gene.^[1]

[edit] References

^ Entrez Gene: OASL 2'-5'-oligoadenylate synthetase-like.

[edit] Further reading

Mackay V, Linn S (1976). "Selective inhibition of the dnase activity of the recBC enzyme by the DNA binding protein from Escherichia coli.". J. Biol. Chem. 251 (12): 3716–9. PMID 776974.
Lee JW, Choi HS, Gyuris J, et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974.
Hartmann R, Olsen HS, Widder S, et al. (1998). "p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family.". Nucleic Acids Res. 26 (18): 4121–8. PMID 9722630.
Rebouillat D, Marié I, Hovanessian AG (1998). "Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase.". Eur. J. Biochem. 257 (2): 319–30. PMID 9826176.
Hovnanian A, Rebouillat D, Levy ER, et al. (1999). "The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus.". Genomics 56 (3): 362–3. doi:10.1006/geno.1998.5737. PMID 10087211.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Andersen JB, Strandbygård DJ, Hartmann R, Justesen J (2004). "Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.". Eur. J. Biochem. 271 (3): 628–36. PMID 14728690.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.