OAS3

From Wikipedia, the free encyclopedia

2'-5'-oligoadenylate synthetase 3, 100kDa

Identifiers

OAS3; p100; MGC133260

External IDs

OMIM: 603351 MGI: 2180850 HomoloGene: 4510

Gene ontology
Molecular Function:	• RNA binding • ATP binding • transferase activity • nucleotidyltransferase activity
Cellular Component:	• microsome
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006187 (mRNA)
NP_006178 (protein)

NM_145226 (mRNA)
NP_660261 (protein)

Location

Chr 12: 111.86 - 111.9 Mb

Chr 5: 121.01 - 121.04 Mb

Pubmed search

[1]

[2]

2'-5'-oligoadenylate synthetase 3, 100kDa, also known as OAS3, is a human gene.^[1]

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.^[1]

[edit] References

^ ^a ^b Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa.

[edit] Further reading

Hovanessian AG, Justesen J (2007). "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.". Biochimie 89 (6-7): 779–88. doi:10.1016/j.biochi.2007.02.003. PMID 17408844.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMID 2440675.
Marié I, Blanco J, Rebouillat D, Hovanessian AG (1997). "69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters.". Eur. J. Biochem. 248 (2): 558–66. PMID 9346316.
Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
Rebouillat D, Hovnanian A, Marié I, Hovanessian AG (1999). "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains.". J. Biol. Chem. 274 (3): 1557–65. PMID 9880533.
Rebouillat D, Hovnanian A, David G, et al. (2001). "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase.". Genomics 70 (2): 232–40. doi:10.1006/geno.2000.6382. PMID 11112351.
Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.". Cancer Res. 61 (5): 2038–46. PMID 11280764.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.