OAS2

From Wikipedia, the free encyclopedia

2'-5'-oligoadenylate synthetase 2, 69/71kDa

Identifiers

OAS2; MGC78578

External IDs

OMIM: 603350 MGI: 2180852 HomoloGene: 49478

Gene ontology
Molecular Function:	• 2'-5'-oligoadenylate synthetase activity • RNA binding • ATP binding • transferase activity
Cellular Component:	• microsome • membrane
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • RNA catabolic process • immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001032731 (mRNA)
NP_001027903 (protein)

NM_145227 (mRNA)
NP_660262 (protein)

Location

Chr 12: 111.9 - 111.93 Mb

Chr 5: 120.99 - 121.01 Mb

Pubmed search

[1]

[2]

2'-5'-oligoadenylate synthetase 2, 69/71kDa, also known as OAS2, is a human gene.^[1]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa.

[edit] Further reading

Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5'-oligoadenylate synthetase family.". Cell. Mol. Life Sci. 57 (11): 1593–612. PMID 11092454.
Marié I, Hovanessian AG (1992). "The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.". J. Biol. Chem. 267 (14): 9933–9. PMID 1577824.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Marié I, Svab J, Robert N, et al. (1990). "Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.". J. Biol. Chem. 265 (30): 18601–7. PMID 2211721.
Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMID 2440675.
Marié I, Galabru J, Svab J, Hovanessian AG (1989). "Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase.". Biochem. Biophys. Res. Commun. 160 (2): 580–7. PMID 2470369.
Hovanessian AG, Svab J, Marié I, et al. (1988). "Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.". J. Biol. Chem. 263 (10): 4945–9. PMID 3350819.
Solinas A, Cossu P, Poddighe P, et al. (1994). "Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C.". Liver 13 (5): 253–8. PMID 8259037.
Besse S, Rebouillat D, Marie I, et al. (1998). "Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells.". Exp. Cell Res. 239 (2): 379–92. PMID 9521856.
Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
Sarkar SN, Ghosh A, Wang HW, et al. (1999). "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.". J. Biol. Chem. 274 (36): 25535–42. PMID 10464285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.