OAS1

From Wikipedia, the free encyclopedia


2',5'-oligoadenylate synthetase 1, 40/46kDa
Identifiers
Symbol(s) OAS1; IFI-4; OIAS; OIASI
External IDs OMIM: 164350 HomoloGene: 1903
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4938 n/a
Ensembl ENSG00000089127 n/a
Refseq NM_001032409 (mRNA)
NP_001027581 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 12: 111.83 - 111.85 Mb n/a
Pubmed search [1] n/a

2',5'-oligoadenylate synthetase 1, 40/46kDa, also known as OAS1, is a human gene.

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

[edit] References

  1. ^ Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa.

[edit] Further reading

  • Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5'-oligoadenylate synthetase family.". Cell. Mol. Life Sci. 57 (11): 1593–612. PMID 11092454. 
  • Ghosh SK, Kusari J, Bandyopadhyay SK, et al. (1991). "Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.". J. Biol. Chem. 266 (23): 15293–9. PMID 1651324. 
  • Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818. 
  • Saunders ME, Gewert DR, Tugwell ME, et al. (1985). "Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.". EMBO J. 4 (7): 1761–8. PMID 2411547. 
  • Benech P, Mory Y, Revel M, Chebath J (1986). "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.". EMBO J. 4 (9): 2249–56. PMID 2416561. 
  • Williams BR, Saunders ME, Willard HF (1986). "Interferon-regulated human 2-5A synthetase gene maps to chromosome 12.". Somat. Cell Mol. Genet. 12 (4): 403–8. PMID 2426799. 
  • Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMID 2440675. 
  • Rutherford MN, Hannigan GE, Williams BR (1988). "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.". EMBO J. 7 (3): 751–9. PMID 2456211. 
  • Benech P, Vigneron M, Peretz D, et al. (1988). "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.". Mol. Cell. Biol. 7 (12): 4498–504. PMID 2830497. 
  • Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.". Eur. J. Biochem. 169 (2): 313–21. PMID 3121313. 
  • Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon.". Somat. Cell Mol. Genet. 14 (5): 415–26. PMID 3175763. 
  • Wathelet M, Moutschen S, Cravador A, et al. (1986). "Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.". FEBS Lett. 196 (1): 113–20. PMID 3753689. 
  • Shiojiri S, Fukunaga R, Ichii Y, Sokawa Y (1986). "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase.". J. Biochem. 99 (5): 1455–64. PMID 3754863. 
  • Merlin G, Chebath J, Benech P, et al. (1983). "Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.". Proc. Natl. Acad. Sci. U.S.A. 80 (16): 4904–8. PMID 6348777. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Ghosh A, Sarkar SN, Guo W, et al. (1998). "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.". J. Biol. Chem. 272 (52): 33220–6. PMID 9407111. 
  • Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745. 
  • Sarkar SN, Ghosh A, Wang HW, et al. (1999). "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.". J. Biol. Chem. 274 (36): 25535–42. PMID 10464285. 
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