O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J0A and 2J0B.

[edit] References

• IUBMB entry for 2.4.1.222
• BRENDA references for 2.4.1.222 (Recommended.)
• PubMed references for 2.4.1.222
• PubMed Central references for 2.4.1.222
• Google Scholar references for 2.4.1.222
• Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406: 369–75. doi:10.1038/35019000. PMID 10935626. 

[edit] External links

The CAS registry number for this enzyme class is 299203-70-6.

• IUBMB entry for 2.4.1.222

• KEGG entry for 2.4.1.222

• BRENDA entry for 2.4.1.222

• NiceZyme view of 2.4.1.222

• EC2PDB: PDB structures for 2.4.1.222

• PRIAM entry for 2.4.1.222

• PUMA2 entry for 2.4.1.222

• IntEnz: Integrated Enzyme entry for 2.4.1.222

• MetaCyc entry for 2.4.1.222

• Atomic-resolution structures of enzymes belonging to this class