O-demethylpuromycin O-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an O-demethylpuromycin O-methyltransferase (EC 2.1.1.38) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + O-demethylpuromycin S-adenosyl-L-homocysteine + puromycin

Thus, the two substrates of this enzyme are S-adenosyl methionine and O-demethylpuromycin, whereas its two products are S-adenosylhomocysteine and puromycin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase. This enzyme is also called O-demethylpuromycin methyltransferase. This enzyme participates in puromycin biosynthesis.

[edit] References

• IUBMB entry for 2.1.1.38
• BRENDA references for 2.1.1.38 (Recommended.)
• PubMed references for 2.1.1.38
• PubMed Central references for 2.1.1.38
• Google Scholar references for 2.1.1.38
• Rao MM, Rebello PF, Pogell BM (1969). "Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin". J. Biol. Chem. 244: 112–8. PMID 5773275. 

[edit] External links

The CAS registry number for this enzyme class is 37257-04-8.

• IUBMB entry for 2.1.1.38

• KEGG entry for 2.1.1.38

• BRENDA entry for 2.1.1.38

• NiceZyme view of 2.1.1.38

• EC2PDB: PDB structures for 2.1.1.38

• PRIAM entry for 2.1.1.38

• PUMA2 entry for 2.1.1.38

• IntEnz: Integrated Enzyme entry for 2.1.1.38

• MetaCyc entry for 2.1.1.38

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030739: O-demethylpuromycin O-methyltransferase

• AMIGO entry for GO code 0030739: O-demethylpuromycin O-methyltransferase