NXPH1

From Wikipedia, the free encyclopedia


Neurexophilin 1
Identifiers
Symbol(s) NXPH1; NPH1; Nbla00697
External IDs OMIM: 604639 MGI: 107492 HomoloGene: 8284
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 30010 18231
Ensembl ENSG00000122584 ENSMUSG00000046178
Uniprot P58417 Q3TQN5
Refseq NM_152745 (mRNA)
NP_689958 (protein)		 NM_008751 (mRNA)
NP_032777 (protein)
Location Chr 7: 8.76 - 8.76 Mb Chr 6: 9.2 - 9.2 Mb
Pubmed search [1] [2]

Neurexophilin 1, also known as NXPH1, is a human gene.[1]

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.[1]

[edit] References

  1. ^ a b Entrez Gene: NXPH1 neurexophilin 1.

[edit] Further reading

  • Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.". Cancer Lett. 197 (1-2): 63–8. PMID 12880961. 
  • Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin.". J. Neurosci. 16 (14): 4360–9. PMID 8699246. 
  • Missler M, Südhof TC (1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins.". J. Neurosci. 18 (10): 3630–8. PMID 9570794. 
  • Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.". J. Biol. Chem. 273 (52): 34716–23. PMID 9856994. 
  • Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
 This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.