NUTF2

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Nuclear transport factor 2
PDB rendering based on 1a2k.
Available structures: 1a2k, 1ar0, 1ask, 1gy5, 1gy6, 1jb2, 1jb4, 1jb5, 1oun, 1qma, 1u5o
Identifiers
Symbol(s) NUTF2; NTF2; PP15
External IDs OMIM: 605813 MGI: 1915301 HomoloGene: 38101
Orthologs
Human Mouse
Entrez 10204 68051


Refseq NM_005796 (mRNA)
NP_005787 (protein)		 NM_026532 (mRNA)
NP_080808 (protein)
Pubmed search [1] [2]

Nuclear transport factor 2, also known as NUTF2, is a human gene.[1]

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[1]

[edit] References

  1. ^ a b Entrez Gene: NUTF2 nuclear transport factor 2.

[edit] Further reading

  • Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.". Mol. Med. 4 (3): 138-43. PMID 9562972. 
  • Stewart M (2001). "Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2).". Cell Struct. Funct. 25 (4): 217-25. PMID 11129791. 
  • Grundmann U, Nerlich C, Rein T, et al. (1988). "Isolation of cDNA coding for the placental protein 15 (PP15).". Nucleic Acids Res. 16 (10): 4721. PMID 3380696. 
  • Bohn H, Johannsen R, Kraus W (1981). "[New placental protein (PP15) with immunosuppressive properties (author's transl)]". Arch. Gynecol. 230 (2): 167-72. PMID 7458421. 
  • Paschal BM, Gerace L (1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.". J. Cell Biol. 129 (4): 925-37. PMID 7744965. 
  • Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.". J. Cell Biol. 134 (3): 589-601. PMID 8707840. 
  • Bullock TL, Clarkson WD, Kent HM, Stewart M (1996). "The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2).". J. Mol. Biol. 260 (3): 422-31. PMID 8757804. 
  • Clarkson WD, Corbett AH, Paschal BM, et al. (1997). "Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.". J. Mol. Biol. 272 (5): 716-30. doi:10.1006/jmbi.1997.1255. PMID 9368653. 
  • Stewart M, Kent HM, McCoy AJ (1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.". J. Mol. Biol. 277 (3): 635-46. doi:10.1006/jmbi.1997.1602. PMID 9533885. 
  • Ribbeck K, Lipowsky G, Kent HM, et al. (1999). "NTF2 mediates nuclear import of Ran.". EMBO J. 17 (22): 6587-98. doi:10.1093/emboj/17.22.6587. PMID 9822603. 
  • Steggerda SM, Black BE, Paschal BM (2000). "Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.". Mol. Biol. Cell 11 (2): 703-19. PMID 10679025. 
  • Freire J, Covelo G, Sarandeses C, et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha.". Biochem. Cell Biol. 79 (2): 123-31. PMID 11310559. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Cushman I, Bowman BR, Sowa ME, et al. (2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.". J. Mol. Biol. 344 (2): 303-10. doi:10.1016/j.jmb.2004.09.043. PMID 15522285. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
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