NUP62

From Wikipedia, the free encyclopedia

Nucleoporin 62kDa

Identifiers

NUP62; p62; DKFZp547L134; FLJ20822; FLJ43869; MGC841

External IDs

OMIM: 605815 MGI: 1351500 HomoloGene: 68773

Gene ontology
Molecular Function:	• chromatin binding • protein serine/threonine kinase activity • nucleocytoplasmic transporter activity • protein binding • porin activity • structural constituent of nuclear pore • receptor signaling complex scaffold activity • transcription regulator activity • SH2 domain binding • ubiquitin binding • thyroid hormone receptor binding
Cellular Component:	• nucleus • nuclear envelope • nuclear pore • cytoplasm • outer membrane • nucleocytoplasmic shuttling complex
Biological Process:	• transport • cell surface receptor linked signal transduction • cell death • negative regulation of cell proliferation • hormone-mediated signaling • regulation of signal transduction • negative regulation of apoptosis • negative regulation of non-apoptotic programmed cell death • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of transcription • regulation of Ras protein signal transduction

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012346 (mRNA)
NP_036478 (protein)

NM_053074 (mRNA)
NP_444304 (protein)

Location

n/a

Chr 7: 44.68 - 44.7 Mb

Pubmed search

[1]

[2]

Nucleoporin 62kDa, also known as NUP62, is a human gene.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.^[1]

[edit] References

^ Entrez Gene: NUP62 nucleoporin 62kDa.

[edit] Further reading

Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics.". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
Geetha T, Wooten MW (2002). "Structure and functional properties of the ubiquitin binding protein p62.". FEBS Lett. 512 (1-3): 19–24. PMID 11852044.
Carmo-Fonseca M, Kern H, Hurt EC (1991). "Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.". Eur. J. Cell Biol. 55 (1): 17–30. PMID 1915414.
Paschal BM, Gerace L (1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.". J. Cell Biol. 129 (4): 925–37. PMID 7744965.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Grote M, Kubitscheck U, Reichelt R, Peters R (1996). "Mapping of nucleoporins to the center of the nuclear pore complex by post-embedding immunogold electron microscopy.". J. Cell. Sci. 108 ( Pt 9): 2963–72. PMID 8537436.
Guan T, Müller S, Klier G, et al. (1996). "Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.". Mol. Biol. Cell 6 (11): 1591–603. PMID 8589458.
Park I, Chung J, Walsh CT, et al. (1996). "Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12338–42. PMID 8618896.
Joung I, Strominger JL, Shin J (1996). "Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 5991–5. PMID 8650207.
Vadlamudi RK, Joung I, Strominger JL, Shin J (1996). "p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.". J. Biol. Chem. 271 (34): 20235–7. PMID 8702753.
Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.". J. Cell Biol. 134 (3): 589–601. PMID 8707840.
Bullock TL, Clarkson WD, Kent HM, Stewart M (1996). "The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2).". J. Mol. Biol. 260 (3): 422–31. PMID 8757804.
Percipalle P, Clarkson WD, Kent HM, et al. (1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.". J. Mol. Biol. 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. PMID 9102465.
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. PMID 9114010.
Yoshima T, Yura T, Yanagi H (1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62.". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kehlenbach RH, Dickmanns A, Kehlenbach A, et al. (1999). "A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.". J. Cell Biol. 145 (4): 645–57. PMID 10330396.
Sanz L, Sanchez P, Lallena MJ, et al. (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.". EMBO J. 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMID 10356400.
Rachubinski RA, Marcus SL, Capone JP (1999). "The p56(lck)-interacting protein p62 stimulates transcription via the SV40 enhancer.". J. Biol. Chem. 274 (26): 18278–84. PMID 10373430.