NUMB (gene)

From Wikipedia, the free encyclopedia

Numb homolog (Drosophila)

PDB rendering based on 1wj1.

Available structures: 1wj1

Identifiers

Symbol(s)

NUMB; S171

External IDs

OMIM: 603728 MGI: 107423 HomoloGene: 2775

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm • early endosome • integral to plasma membrane • membrane • extrinsic to plasma membrane • apical part of cell
Biological Process:	• multicellular organismal development • nervous system development • neuroblast proliferation • axonogenesis • forebrain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001005743 (mRNA)
NP_001005743 (protein)

NM_010949 (mRNA)
NP_035079 (protein)

Location

Chr 14: 72.81 - 72.99 Mb

Chr 12: 84.69 - 84.73 Mb

Pubmed search

[1]

[2]

Numb homolog (Drosophila), also known as NUMB, is a human gene.

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ Entrez Gene: NUMB numb homolog (Drosophila).

[edit] Further reading

Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. PMID 7568168.
Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.". Nature 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406.
Zhong W, Feder JN, Jiang MM, et al. (1996). "Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.". Neuron 17 (1): 43–53. PMID 8755477.
Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.". Genes Dev. 11 (17): 2239–49. PMID 9303539.
Dho SE, Jacob S, Wolting CD, et al. (1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.". J. Biol. Chem. 273 (15): 9179–87. PMID 9535908.
Juven-Gershon T, Shifman O, Unger T, et al. (1998). "The Mdm2 oncoprotein interacts with the cell fate regulator Numb.". Mol. Cell. Biol. 18 (7): 3974–82. PMID 9632782.
Verdi JM, Bashirullah A, Goldhawk DE, et al. (1999). "Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10472–6. PMID 10468633.
Santolini E, Puri C, Salcini AE, et al. (2001). "Numb is an endocytic protein.". J. Cell Biol. 151 (6): 1345–52. PMID 11121447.
Susini L, Passer BJ, Amzallag-Elbaz N, et al. (2002). "Siah-1 binds and regulates the function of Numb.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15067–72. doi:10.1073/pnas.261571998. PMID 11752454.
Nie J, McGill MA, Dermer M, et al. (2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.". EMBO J. 21 (1-2): 93–102. doi:10.1093/emboj/21.1.93. PMID 11782429.
Rice DS, Northcutt GM, Kurschner C (2002). "The Lnx family proteins function as molecular scaffolds for Numb family proteins.". Mol. Cell. Neurosci. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID 11922143.
Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7102–7. doi:10.1073/pnas.102192599. PMID 12011466.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. doi:10.1073/pnas.262791999. PMID 12606711.
Yogosawa S, Miyauchi Y, Honda R, et al. (2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase.". Biochem. Biophys. Res. Commun. 302 (4): 869–72. PMID 12646252.
McGill MA, McGlade CJ (2003). "Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.". J. Biol. Chem. 278 (25): 23196–203. doi:10.1074/jbc.M302827200. PMID 12682059.
Rossé C, L'Hoste S, Offner N, et al. (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.
Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088.
Qin H, Percival-Smith A, Li C, et al. (2004). "A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.". J. Biol. Chem. 279 (12): 11304–12. doi:10.1074/jbc.M311733200. PMID 14670962.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.