NUDT9

From Wikipedia, the free encyclopedia

Nudix (nucleoside diphosphate linked moiety X)-type motif 9

PDB rendering based on 1q33.

Available structures: 1q33, 1qvj

Identifiers

Symbol(s)

NUDT9; MGC3037; NUDT10

External IDs

OMIM: 606022 MGI: 1921417 HomoloGene: 11435

Gene ontology
Molecular Function:	• magnesium ion binding • calcium activated cation channel activity • hydrolase activity • nucleoside-diphosphatase activity • ADP-sugar diphosphatase activity • manganese ion binding • ADP-ribose diphosphatase activity
Cellular Component:	• intracellular • mitochondrion
Biological Process:	• cation transport • ADP catabolic process • IDP catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_024047 (mRNA)
NP_076952 (protein)

XM_980297 (mRNA)
XP_985391 (protein)

Location

Chr 4: 88.56 - 88.6 Mb

n/a

Pubmed search

[1]

[2]

Nudix (nucleoside diphosphate linked moiety X)-type motif 9, also known as NUDT9, is a human gene.^[1]

[edit] References

^ Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9.

[edit] Further reading

Perraud AL, Fleig A, Dunn CA, et al. (2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.". Nature 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.
Lin S, Gasmi L, Xie Y, et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).". Biochim. Biophys. Acta 1594 (1): 127–35. PMID 11825615.
Perraud AL, Shen B, Dunn CA, et al. (2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.". J. Biol. Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang HT, Yan ZQ, Hu XB, et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method.". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35 (8): 747–51. PMID 12897971.
Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9.". J. Mol. Biol. 332 (2): 385–98. PMID 12948489.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Carloto A, Costas MJ, Cameselle JC, et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.". Biochim. Biophys. Acta 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.