NUDT5

From Wikipedia, the free encyclopedia

Nudix (nucleoside diphosphate linked moiety X)-type motif 5

PDB rendering based on 2dsb.

Available structures: 2dsb, 2dsc, 2dsd

Identifiers

Symbol(s)

NUDT5; YSA1H; hYSAH1

External IDs

OMIM: 609230 MGI: 1858232 HomoloGene: 5388

Gene ontology
Molecular Function:	• magnesium ion binding • protein binding • hydrolase activity • ADP-sugar diphosphatase activity • ADP-ribose diphosphatase activity • ADP reductase activity
Cellular Component:	• intracellular
Biological Process:	• nucleotide metabolic process • ribonucleoside diphosphate catabolic process • D-ribose catabolic process

Orthologs

Human

Mouse

Refseq

NM_014142 (mRNA)
NP_054861 (protein)

NM_016918 (mRNA)
NP_058614 (protein)

Location

Chr 10: 12.25 - 12.28 Mb

Chr 2: 5.76 - 5.79 Mb

Pubmed search

[1]

[2]

Nudix (nucleoside diphosphate linked moiety X)-type motif 5, also known as NUDT5, is a human gene.^[1]

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5.

[edit] Further reading

McLennan AG (1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review).". Int. J. Mol. Med. 4 (1): 79–89. PMID 10373642.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMID 12717453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse.". J. Biol. Chem. 275 (12): 8844–53. PMID 10722730.
Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.". Biochem. J. 344 Pt 2: 331–7. PMID 10567213.