Nucleotide diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a nucleotide diphosphatase (EC 3.6.1.9) is an enzyme that catalyzes the chemical reaction

a dinucleotide + H₂O $\rightleftharpoons$ 2 mononucleotides

Thus, the two substrates of this enzyme are dinucleotide and H₂O, whereas its product is mononucleotide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include nucleotide pyrophosphatase, and nucleotide-sugar pyrophosphatase. This enzyme participates in 5 metabolic pathways: purine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, and pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1NQY, 1NQZ, 2GSN, 2GSO, and 2GSU.

[edit] References

IUBMB entry for 3.6.1.9
BRENDA references for 3.6.1.9 (Recommended.)
PubMed references for 3.6.1.9
PubMed Central references for 3.6.1.9
Google Scholar references for 3.6.1.9
Jacobson JB and Kaplan NO (1957). "A reduced pyridine nucleotide pyrophosphatase". J. Biol. Chem. 226: 427–437.
Kornberg A and Pricer WE (1950). "Nucleotide pyrophosphatase". J. Biol. Chem. 182: 763–778.
Kumar SA, Rao NA, Vaidyanathan CS (1965). "Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus)". Arch. Biochem. Biophys. 111: 646–52. doi:10.1016/0003-9861(65)90246-8. PMID 5862212.
Swartz MN, Kaplan NO and Lamborg MF (1958). "A "heat-activated" diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris". J. Biol. Chem. 232: 1051–1063.