Nucleoside-triphosphate diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a nucleoside-triphosphate diphosphatase (EC 3.6.1.19) is an enzyme that catalyzes the chemical reaction

a nucleoside triphosphate + H₂O a nucleotide + diphosphate

Thus, the two substrates of this enzyme are nucleoside triphosphate and H₂O, whereas its two products are nucleotide and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is nucleoside-triphosphate diphosphohydrolase. This enzyme is also called nucleoside-triphosphate pyrophosphatase. This enzyme participates in purine metabolism and pyrimidine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1V7R, 2CAR, 2E5X, 2I5D, and 2J4E.

[edit] References

• IUBMB entry for 3.6.1.19
• BRENDA references for 3.6.1.19 (Recommended.)
• PubMed references for 3.6.1.19
• PubMed Central references for 3.6.1.19
• Google Scholar references for 3.6.1.19
• Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit". J. Biol. Chem. 244: 5489–95. PMID 4310599. 

[edit] External links

The CAS registry number for this enzyme class is 9075-54-1.

• IUBMB entry for 3.6.1.19

• KEGG entry for 3.6.1.19

• BRENDA entry for 3.6.1.19

• NiceZyme view of 3.6.1.19

• EC2PDB: PDB structures for 3.6.1.19

• PRIAM entry for 3.6.1.19

• PUMA2 entry for 3.6.1.19

• IntEnz: Integrated Enzyme entry for 3.6.1.19

• MetaCyc entry for 3.6.1.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047429: nucleoside-triphosphate diphosphatase

• AMIGO entry for GO code 0047429: nucleoside-triphosphate diphosphatase