Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

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In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.28) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + alpha-D-aldose 1-phosphate $\rightleftharpoons$ diphosphate + NDP-hexose

Thus, the two substrates of this enzyme are nucleoside triphosphate and alpha-D-aldose 1-phosphate, whereas its two products are diphosphate and NDP-hexose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase. Other names in common use include NDP hexose pyrophosphorylase, hexose 1-phosphate nucleotidyltransferase, hexose nucleotidylating enzyme, nucleoside diphosphohexose pyrophosphorylase, hexose-1-phosphate guanylyltransferase, GTP:alpha-D-hexose-1-phosphate guanylyltransferase, GDP hexose pyrophosphorylase, guanosine diphosphohexose pyrophosphorylase, nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase, and NTP:hexose-1-phosphate nucleotidyltransferase.

[edit] References

IUBMB entry for 2.7.7.28
BRENDA references for 2.7.7.28 (Recommended.)
PubMed references for 2.7.7.28
PubMed Central references for 2.7.7.28
Google Scholar references for 2.7.7.28
Verachtert H, Rodriguez P, Bass ST, Hansen RG (1966). "Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues". J. Biol. Chem. 241: 2007–13. PMID 5946626.
Hansen RG, Verachtert H, Rodriguez P and Bass ST (1966). "GDP-hexose pyrophosphorylase from liver". Methods Enzymol. 8: 269–271.