NRD1

From Wikipedia, the free encyclopedia

Nardilysin (N-arginine dibasic convertase)

Identifiers

NRD1; hNRD1; hNRD2

External IDs

OMIM: 602651 MGI: 1201386 HomoloGene: 68260

Gene ontology
Molecular Function:	• metalloendopeptidase activity • zinc ion binding • nardilysin activity • metal ion binding • epidermal growth factor binding
Cellular Component:	• cytosol • cell surface
Biological Process:	• proteolysis • neuromuscular junction development • cell proliferation • cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002525 (mRNA)
NP_002516 (protein)

NM_146150 (mRNA)
NP_666262 (protein)

Location

Chr 1: 52.03 - 52.12 Mb

Chr 4: 108.5 - 108.56 Mb

Pubmed search

[1]

[2]

Nardilysin (N-arginine dibasic convertase), also known as NRD1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase).

[edit] Further reading

Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu.". Essays Biochem. 38: 79-94. PMID 12463163.
Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.". Protein Pept. Lett. 11 (5): 501-8. PMID 15544571.
Fumagalli P, Accarino M, Egeo A, et al. (1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues.". Genomics 47 (2): 238-45. doi:10.1006/geno.1997.5078. PMID 9479496.
Hospital V, Prat A, Joulie C, et al. (1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family.". Biochem. J. 327 ( Pt 3): 773-9. PMID 9581555.
Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.". Biochem. J. 351 Pt 3: 755-64. PMID 11042131.
Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.". EMBO J. 20 (13): 3342-50. doi:10.1093/emboj/20.13.3342. PMID 11432822.
Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain.". Biochemistry 40 (31): 9447-52. PMID 11478915.
Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).". Biochem. J. 367 (Pt 1): 229-38. doi:10.1042/BJ20020822. PMID 12095415.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites.". Biochemistry 42 (7): 2239-44. doi:10.1021/bi027178d. PMID 12590613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.". J. Biol. Chem. 281 (41): 31164-72. doi:10.1074/jbc.M601316200. PMID 16923819.
Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons.". Neuroscience 146 (4): 1513-23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499.