NPR1

From Wikipedia, the free encyclopedia

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Identifiers

NPR1; ANPRA; ANPa; GUC2A; GUCY2A; NPRA

External IDs

OMIM: 108960 MGI: 97371 HomoloGene: 37367

Gene ontology
Molecular Function:	• guanylate cyclase activity • protein-tyrosine kinase activity • receptor activity • ATP binding • peptide receptor activity, G-protein coupled • chloride ion binding • hormone binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cGMP biosynthetic process • protein amino acid phosphorylation • cell surface receptor linked signal transduction • intracellular signaling cascade • fluid secretion • blood pressure regulation • negative regulation of angiogenesis • diuresis • natriuresis • negative regulation of cell growth • regulation of vasodilation • regulation of vascular permeability

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000906 (mRNA)
NP_000897 (protein)

NM_008727 (mRNA)
NP_032753 (protein)

Location

Chr 1: 151.92 - 151.93 Mb

Chr 3: 90.54 - 90.55 Mb

Pubmed search

[1]

[2]

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is a human gene.

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM]^[1]

1 References
2 Further reading
3 See also
4 External links

[edit] References

^ Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A).

[edit] Further reading

Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1-2): 61-72. PMID 11952097.
Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 3 (11): 1085-91. PMID 12506509.
Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A.". Peptides 26 (6): 985-1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067.
Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression.". Peptides 26 (6): 1009-23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069.