NPLOC4

From Wikipedia, the free encyclopedia

Nuclear protein localization 4 homolog (S. cerevisiae)

PDB rendering based on 1nj3.

Available structures: 1nj3, 1q5w, 2pjh

Identifiers

Symbol(s)

NPLOC4; FLJ20657; FLJ23742; KIAA1499; NPL4

External IDs

OMIM: 606590 MGI: 2679787 HomoloGene: 5403

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus • endoplasmic reticulum • nuclear envelope-endoplasmic reticulum network
Biological Process:	• protein folding • ubiquitin cycle • membrane fusion • Golgi organization and biogenesis • ER-associated protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017921 (mRNA)
NP_060391 (protein)

NM_199469 (mRNA)
NP_955763 (protein)

Location

Chr 17: 77.13 - 77.23 Mb

Chr 11: 120.2 - 120.25 Mb

Pubmed search

[1]

[2]

Nuclear protein localization 4 homolog (S. cerevisiae), also known as NPLOC4, is a human gene.^[1]

[edit] References

^ Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae).

[edit] Further reading

McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation.". Biochem. Biophys. Res. Commun. 355 (4): 1087-90. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Botta A, Tandoi C, Fini G, et al. (2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).". Gene 275 (1): 39-46. PMID 11574150.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143-50. PMID 10819331.
Meyer HH, Shorter JG, Seemann J, et al. (2000). "A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.". EMBO J. 19 (10): 2181-92. doi:10.1093/emboj/19.10.2181. PMID 10811609.