NPFF

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Neuropeptide FF-amide peptide precursor
Identifiers
Symbol(s) NPFF; FMRFAL
External IDs OMIM: 604643 MGI: 1891708 HomoloGene: 48236
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8620 54615
Ensembl ENSG00000139574 ENSMUSG00000023052
Uniprot O15130 Q9WVA8
Refseq NM_003717 (mRNA)
NP_003708 (protein)		 NM_018787 (mRNA)
NP_061257 (protein)
Location Chr 12: 52.19 - 52.19 Mb Chr 15: 102.35 - 102.35 Mb
Pubmed search [1] [2]

Neuropeptide FF-amide peptide precursor, also known as NPFF, is a human gene.[1]

FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function.[1]

[edit] References

  1. ^ a b Entrez Gene: NPFF neuropeptide FF-amide peptide precursor.

[edit] Further reading

  • Panula P, Aarnisalo AA, Wasowicz K (1996). "Neuropeptide FF, a mammalian neuropeptide with multiple functions.". Prog. Neurobiol. 48 (4-5): 461–87. PMID 8804117. 
  • Sundblom DM, Panula P, Fyhrquist F (1995). "Neuropeptide FF-like immunoreactivity in human plasma.". Peptides 16 (2): 347–50. PMID 7784266. 
  • Perry SJ, Yi-Kung Huang E, Cronk D, et al. (1997). "A human gene encoding morphine modulating peptides related to NPFF and FMRFamide.". FEBS Lett. 409 (3): 426–30. PMID 9224703. 
  • Sundblom DM, Hyrkkö A, Fyhrquist F (1998). "Pulsatile secretion of neuropeptide FF into human blood.". Peptides 19 (7): 1165–70. PMID 9786165. 
  • Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242. 
  • Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF.". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015. 
  • Mollereau C, Gouardères C, Dumont Y, et al. (2001). "Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226.". Br. J. Pharmacol. 133 (1): 1–4. doi:10.1038/sj.bjp.0704049. PMID 11325787. 
  • Catarsi S, Babinski K, Séguéla P (2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF.". Neuropharmacology 41 (5): 592–600. PMID 11587714. 
  • Lefrere I, De Coppet P, Camelin JC, et al. (2002). "Neuropeptide AF and FF modulation of adipocyte metabolism. Primary insights from functional genomics and effects on beta-adrenergic responsiveness.". J. Biol. Chem. 277 (42): 39169–78. doi:10.1074/jbc.M205084200. PMID 12149260. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus.". Regul. Pept. 111 (1-3): 21–9. PMID 12609745. 
  • Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216. 
  • Roumy M, Lorenzo C, Mazères S, et al. (2007). "Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.". J. Biol. Chem. 282 (11): 8332–42. doi:10.1074/jbc.M606946200. PMID 17224450. 
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