NPAT (gene)

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Nuclear protein, ataxia-telangiectasia locus
Identifiers
Symbol(s) NPAT; E14
External IDs OMIM: 601448 MGI: 107605 HomoloGene: 1888
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4863 244879
Ensembl ENSG00000149308 ENSMUSG00000033054
Refseq NM_002519 (mRNA)
NP_002510 (protein)		 XM_146900 (mRNA)
XP_146900 (protein)
Location Chr 11: 107.53 - 107.6 Mb Chr 9: 53.3 - 53.34 Mb
Pubmed search [1] [2]

Nuclear protein, ataxia-telangiectasia locus, also known as NPAT, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus.

[edit] Further reading

  • Imai T, Yamauchi M, Seki N, et al. (1996). "Identification and characterization of a new gene physically linked to the ATM gene.". Genome Res. 6 (5): 439-47. PMID 8743993. 
  • Byrd PJ, McConville CM, Cooper P, et al. (1996). "Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.". Hum. Mol. Genet. 5 (1): 145-9. PMID 8789452. 
  • Byrd PJ, Cooper PR, Stankovic T, et al. (1997). "A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies.". Hum. Mol. Genet. 5 (11): 1785-91. PMID 8923007. 
  • Imai T, Sugawara T, Nishiyama A, et al. (1997). "The structure and organization of the human NPAT gene.". Genomics 42 (3): 388-92. PMID 9205109. 
  • Zhao J, Dynlacht B, Imai T, et al. (1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.". Genes Dev. 12 (4): 456-61. PMID 9472014. 
  • Zhao J, Kennedy BK, Lawrence BD, et al. (2000). "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.". Genes Dev. 14 (18): 2283-97. PMID 10995386. 
  • Sagara M, Takeda E, Nishiyama A, et al. (2004). "Characterization of functional regions for nuclear localization of NPAT.". J. Biochem. 132 (6): 875-9. PMID 12473189. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gao G, Bracken AP, Burkard K, et al. (2003). "NPAT expression is regulated by E2F and is essential for cell cycle progression.". Mol. Cell. Biol. 23 (8): 2821-33. PMID 12665581. 
  • Wei Y, Jin J, Harper JW (2003). "The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.". Mol. Cell. Biol. 23 (10): 3669-80. PMID 12724424. 
  • Zheng L, Roeder RG, Luo Y (2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.". Cell 114 (2): 255-66. PMID 12887926. 
  • Ye X, Wei Y, Nalepa G, Harper JW (2003). "The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.". Mol. Cell. Biol. 23 (23): 8586-600. PMID 14612403. 
  • Wang A, Ikura T, Eto K, Ota MS (2005). "Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry.". Biochem. Biophys. Res. Commun. 325 (4): 1509-16. doi:10.1016/j.bbrc.2004.10.198. PMID 15555599. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Kalla C, Scheuermann MO, Kube I, et al. (2007). "Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.". Eur. J. Cancer 43 (8): 1328-35. doi:10.1016/j.ejca.2007.02.005. PMID 17449237. 
  • Medina R, van der Deen M, Miele-Chamberland A, et al. (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.". Cancer Res. 67 (21): 10334-42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976. 
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