North Carolina Highway 157

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North Carolina Highway 157 is a north - south highway that goes from Interstate 85, U.S. 15/501/70 Bypass, in Durham, to N.C. 57 & U.S. 501, in Roxboro, North Carolina. It is called Guess Road, while it is in Durham, and goes through the major places of Durham, Hillsborough, and Roxboro.