NOMO1

From Wikipedia, the free encyclopedia

NODAL modulator 1

Identifiers

NOMO1; Nomo; PM5

External IDs

OMIM: 609157 MGI: 2385850 HomoloGene: 13810

Gene ontology
Molecular Function:	• catalytic activity • ferric iron binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• aromatic compound metabolic process

Orthologs

Human

Mouse

n/a

Refseq

NM_014287 (mRNA)
NP_055102 (protein)

NM_153057 (mRNA)
NP_694697 (protein)

Location

n/a

Chr 7: 45.9 - 45.95 Mb

Pubmed search

[1]

[2]

NODAL modulator 1, also known as NOMO1, is a human gene.^[1]

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).^[1]

[edit] References

^ ^a ^b Entrez Gene: NOMO1 NODAL modulator 1.

[edit] Further reading

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
Haffner C, Frauli M, Topp S, et al. (2005). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMID 15257293.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
van Soest S, Swart J, Tijmes N, et al. (1997). "A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.". Genome Res. 7 (8): 830–4. PMID 9267806.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Templeton NS, Rodgers LA, Levy AT, et al. (1992). "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family.". Genomics 12 (1): 175–6. PMID 1310294.