NOL6

From Wikipedia, the free encyclopedia

Nucleolar protein family 6 (RNA-associated)

Identifiers

NOL6; NRAP; FLJ21959; MGC14896; MGC14921; MGC20838; UTP22; bA311H10.1

External IDs

Gene ontology
Molecular Function:	• protein binding • snoRNA binding
Cellular Component:	• condensed nuclear chromosome • nucleus • nucleolus • small nucleolar ribonucleoprotein complex
Biological Process:	• 35S primary transcript processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_130793 (mRNA)
NP_570611 (protein)

NM_139237 (mRNA)
NP_631983 (protein)

Location

Chr 9: 33.45 - 33.46 Mb

Chr 4: 41.3 - 41.31 Mb

Pubmed search

[1]

[2]

Nucleolar protein family 6 (RNA-associated), also known as NOL6, is a human gene.^[1]

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated).

[edit] Further reading

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Utama B, Kennedy D, Ru K, Mattick JS (2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans.". Genes Cells 7 (2): 115-32. PMID 11895476.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Bernstein KA, Gallagher JE, Mitchell BM, et al. (2005). "The small-subunit processome is a ribosome assembly intermediate.". Eukaryotic Cell 3 (6): 1619-26. doi:10.1128/EC.3.6.1619-1626.2004. PMID 15590835.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.