NODAL

From Wikipedia, the free encyclopedia

Nodal homolog (mouse)

Identifiers

NODAL; MGC138230

External IDs

OMIM: 601265 MGI: 97359 HomoloGene: 8417

Gene ontology
Molecular Function:	• cytokine activity • growth factor activity
Cellular Component:	• extracellular space
Biological Process:	• in utero embryonic development • heart looping • repression of premature neural plate formation • multicellular organismal development • determination of left/right symmetry • positive regulation of cell proliferation • anterior/posterior pattern formation • stem cell maintenance • cell migration involved in gastrulation • cell fate commitment

Orthologs

Human

Mouse

Refseq

NM_018055 (mRNA)
NP_060525 (protein)

NM_013611 (mRNA)
NP_038639 (protein)

Location

Chr 10: 71.86 - 71.87 Mb

Chr 10: 60.81 - 60.82 Mb

Pubmed search

[1]

[2]

Nodal homolog (mouse), also known as NODAL, is a human gene.^[1]

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.^[1]

[edit] References

^ ^a ^b Entrez Gene: NODAL nodal homolog (mouse).

[edit] Further reading

Postovit LM, Seftor EA, Seftor RE, Hendrix MJ (2007). "Targeting Nodal in malignant melanoma cells.". Expert Opin. Ther. Targets 11 (4): 497–505. doi:10.1517/14728222.11.4.497. PMID 17373879.
Zhou X, Sasaki H, Lowe L, et al. (1993). "Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.". Nature 361 (6412): 543–7. doi:10.1038/361543a0. PMID 8429908.
Gebbia M, Ferrero GB, Pilia G, et al. (1997). "X-linked situs abnormalities result from mutations in ZIC3.". Nat. Genet. 17 (3): 305–8. doi:10.1038/ng1197-305. PMID 9354794.
Yan YT, Liu JJ, Luo Y, et al. (2002). "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.". Mol. Cell. Biol. 22 (13): 4439–49. PMID 12052855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID 12606401.
Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID 15150278.
Haffner C, Frauli M, Topp S, et al. (2005). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMID 15257293.
Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
Bamforth SD, Bragança J, Farthing CR, et al. (2004). "Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.". Nat. Genet. 36 (11): 1189–96. doi:10.1038/ng1446. PMID 15475956.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Vallier L, Reynolds D, Pedersen RA (2005). "Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway.". Dev. Biol. 275 (2): 403–21. doi:10.1016/j.ydbio.2004.08.031. PMID 15501227.
Hart AH, Willson TA, Wong M, et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.
Vallier L, Alexander M, Pedersen RA (2006). "Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.". J. Cell. Sci. 118 (Pt 19): 4495–509. doi:10.1242/jcs.02553. PMID 16179608.