NMI (gene)

From Wikipedia, the free encyclopedia

N-myc (and STAT) interactor

Identifiers

External IDs

OMIM: 603525 MGI: 1928368 HomoloGene: 3441

Gene ontology
Molecular Function:	• transcription cofactor activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• transcription from RNA polymerase II promoter • inflammatory response • JAK-STAT cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004688 (mRNA)
NP_004679 (protein)

NM_019401 (mRNA)
NP_062274 (protein)

Location

Chr 2: 151.84 - 151.85 Mb

Chr 2: 51.77 - 51.8 Mb

Pubmed search

[1]

[2]

N-myc (and STAT) interactor, also known as NMI, is a human gene.^[1]

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.^[1]

[edit] References

^ ^a ^b Entrez Gene: NMI N-myc (and STAT) interactor.

[edit] Further reading

Bao J, Zervos AS (1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins.". Oncogene 12 (10): 2171–6. PMID 8668343.
Lebrun SJ, Shpall RL, Naumovski L (1998). "Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi.". J. Interferon Cytokine Res. 18 (9): 767–71. PMID 9781816.
Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.". Cell 96 (1): 121–30. PMID 9989503.
Lee ND, Chen J, Shpall RL, Naumovski L (1999). "Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain.". J. Interferon Cytokine Res. 19 (11): 1245–52. doi:10.1089/107999099312902. PMID 10574616.
Bannasch D, Weis I, Schwab M (2000). "Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN.". Oncogene 18 (48): 6810–7. doi:10.1038/sj.onc.1203090. PMID 10597290.
Zhou X, Liao J, Meyerdierks A, et al. (2000). "Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35.". J. Biol. Chem. 275 (28): 21364–71. doi:10.1074/jbc.M003177200. PMID 10779520.
Chen J, Shpall RL, Meyerdierks A, et al. (2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35.". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.
Chen J, Naumovski L (2002). "Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells.". J. Interferon Cytokine Res. 22 (2): 237–43. doi:10.1089/107999002753536211. PMID 11911807.
Li H, Lee TH, Avraham H (2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.
Sun GJ, Tong X, Dong Y, et al. (2002). "[Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (3): 369–72. PMID 12019454.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Jung HH, Lee J, Kim JH, et al. (2005). "STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell.". FEBS Lett. 579 (18): 3941–6. doi:10.1016/j.febslet.2005.06.011. PMID 15996661.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Schlierf B, Lang S, Kosian T, et al. (2005). "The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi.". J. Mol. Biol. 353 (5): 1033–42. doi:10.1016/j.jmb.2005.09.013. PMID 16214168.
Zhang L, Tang Y, Tie Y, et al. (2007). "The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.". Cell. Signal. 19 (5): 932–44. doi:10.1016/j.cellsig.2006.11.002. PMID 17197158.
Albihn A, Mo H, Yang Y, Henriksson M (2007). "Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling.". Int. J. Cancer 121 (8): 1821–9. doi:10.1002/ijc.22866. PMID 17565738.