NME1

From Wikipedia, the free encyclopedia

Non-metastatic cells 1, protein (NM23A) expressed in

PDB rendering based on 1be4.

Available structures: 1be4, 1bhn, 1jxv, 1ucn, 2hvd, 2hve

Identifiers

Symbol(s)

NME1; AWD; GAAD; NDPKA; NM23; NM23-H1

External IDs

OMIM: 156490 MGI: 97355 HomoloGene: 56418

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • DNA binding • deoxyribonuclease activity • nucleoside diphosphate kinase activity • ATP binding • kinase activity • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• GTP biosynthetic process • UTP biosynthetic process • CTP biosynthetic process • cell cycle • negative regulation of cell proliferation • nucleotide metabolic process • nucleoside triphosphate biosynthetic process • regulation of apoptosis • negative regulation of progression through cell cycle

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_000269 (mRNA)
NP_000260 (protein)

XM_982532 (mRNA)
XP_987626 (protein)

Location

n/a

Chr 11: 93.77 - 93.78 Mb

Pubmed search

[1]

[2]

Non-metastatic cells 1, protein (NM23A) expressed in, also known as NME1, is a human gene. It is thought to be a metastasis suppressor.

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.^[1]

[edit] See also

Nucleoside-diphosphate kinase

[edit] References

^ Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in.

[edit] Further reading

Freije JM, MacDonald NJ, Steeg PS (1998). "Nm23 and tumour metastasis: basic and translational advances.". Biochem. Soc. Symp. 63: 261–71. PMID 9513729.
Roymans D, Willems R, Van Blockstaele DR, Slegers H (2002). "Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis.". Clin. Exp. Metastasis 19 (6): 465–76. PMID 12405283.
Tee YT, Chen GD, Lin LY, et al. (2007). "Nm23-H1: a metastasis-associated gene.". Taiwanese journal of obstetrics & gynecology 45 (2): 107–13. PMID 17197349.
Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158.
Leone A, McBride OW, Weston A, et al. (1991). "Somatic allelic deletion of nm23 in human cancer.". Cancer Res. 51 (9): 2490–3. PMID 2015608.
Hailat N, Keim DR, Melhem RF, et al. (1991). "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.". J. Clin. Invest. 88 (1): 341–5. PMID 2056128.
Rosengard AM, Krutzsch HC, Shearn A, et al. (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.". Nature 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941.
Wang L, Patel U, Ghosh L, et al. (1993). "Mutation in the nm23 gene is associated with metastasis in colorectal cancer.". Cancer Res. 53 (4): 717–20. PMID 7916650.
Chang CL, Zhu XX, Thoraval DH, et al. (1994). "Nm23-H1 mutation in neuroblastoma.". Nature 370 (6488): 335–6. doi:10.1038/370335a0. PMID 8047138.
MacDonald NJ, De la Rosa A, Benedict MA, et al. (1994). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.". J. Biol. Chem. 268 (34): 25780–9. PMID 8245015.
Dooley S, Seib T, Engel M, et al. (1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1.". Hum. Genet. 93 (1): 63–6. PMID 8270257.
Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.". Science 261 (5120): 478–80. PMID 8392752.
Sudbrak R, Golla A, Hogan K, et al. (1993). "Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect.". Hum. Mol. Genet. 2 (7): 857–62. PMID 8395939.
MacDonald NJ, Freije JM, Stracke ML, et al. (1996). "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.". J. Biol. Chem. 271 (41): 25107–16. PMID 8810265.
Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
Nosaka K, Kawahara M, Masuda M, et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.
Schaertl S, Konrad M, Geeves MA (1998). "Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis.". J. Biol. Chem. 273 (10): 5662–9. PMID 9488696.
Willems R, Van Bockstaele DR, Lardon F, et al. (1998). "Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation.". J. Biol. Chem. 273 (22): 13663–8. PMID 9593706.
Manda R, Kohno T, Matsuno Y, et al. (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.". Genomics 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675.