NKTR

From Wikipedia, the free encyclopedia

Natural killer-tumor recognition sequence

PDB rendering based on 2he9.

Available structures: 2he9

Identifiers

Symbol(s)

NKTR; DKFZp686F1754; DKFZp686G0426; DKFZp686J06106; DKFZp686N24126; MGC90527; p104

External IDs

OMIM: 161565 MGI: 97346 HomoloGene: 38042

Gene ontology
Molecular Function:	• peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding • isomerase activity
Cellular Component:	• plasma membrane
Biological Process:	• protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012651 (mRNA)
NP_001012669 (protein)

NM_010918 (mRNA)
NP_035048 (protein)

Location

Chr 3: 42.62 - 42.67 Mb

Chr 9: 121.57 - 121.61 Mb

Pubmed search

[1]

[2]

Natural killer-tumor recognition sequence, also known as NKTR, is a human gene.^[1]

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: NKTR natural killer-tumor recognition sequence.

[edit] Further reading

Frey JL, Bino T, Kantor RR, et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes.". J. Exp. Med. 174 (6): 1527–36. PMID 1720812.
Chambers CA, Gallinger S, Anderson SK, et al. (1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells.". J. Immunol. 152 (6): 2669–74. PMID 8144875.
Young HA, Jenkins NA, Copeland NG, et al. (1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9.". Genomics 16 (2): 548–9. doi:10.1006/geno.1993.1229. PMID 8314596.
Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism.". Mol. Immunol. 30 (14): 1307–13. PMID 8413330.
Anderson SK, Gallinger S, Roder J, et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells.". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–6. PMID 8421688.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.". Mol. Cell. Biol. 24 (3): 1174–87. PMID 14729963.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.