Nitroalkane oxidase

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In enzymology, a nitroalkane oxidase (EC 1.7.3.1) is an enzyme that catalyzes the chemical reaction

a nitroalkane + H₂O + O₂ an aldehyde or ketone + nitrite + H₂O₂

The 3 substrates of this enzyme are nitroalkane, H₂O, and O₂, whereas its 4 products are aldehyde, ketone, nitrite, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is nitroalkane:oxygen oxidoreductase. Other names in common use include nitroethane oxidase, NAO, and nitroethane:oxygen oxidoreductase. This enzyme participates in nitrogen metabolism.

[edit] References

• IUBMB entry for 1.7.3.1
• BRENDA references for 1.7.3.1 (Recommended.)
• PubMed references for 1.7.3.1
• PubMed Central references for 1.7.3.1
• Google Scholar references for 1.7.3.1
• LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora". J. Biol. Chem. 193: 347–58. PMID 14907722. 
• Kido T, Hashizume K, Soda K (1978). "Purification and properties of nitroalkane oxidase from Fusarium oxysporum". J. Bacteriol. 133: 53–8. PMID 22538. 
• Daubner SC, Gadda G, Valley MP, Fitzpatrick PF (2002). "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily". Proc. Natl. Acad. Sci. U. S. A. 99: 2702–7. PMID 11867731. 
• Fitzpatrick PF, Orville AM, Nagpal A, Valley MP (2005). "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase". Arch. Biochem. Biophys. 433: 157–65. PMID 15581574. 
• Valley MP, Tichy SE, Fitzpatrick PF (2005). "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase". J. Am. Chem. Soc. 127: 2062–6. PMID 15713081. 

[edit] External links

The CAS registry number for this enzyme class is 9029-36-1.

• IUBMB entry for 1.7.3.1

• KEGG entry for 1.7.3.1

• BRENDA entry for 1.7.3.1

• NiceZyme view of 1.7.3.1

• EC2PDB: PDB structures for 1.7.3.1

• PRIAM entry for 1.7.3.1

• PUMA2 entry for 1.7.3.1

• IntEnz: Integrated Enzyme entry for 1.7.3.1

• MetaCyc entry for 1.7.3.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050141: nitroethane oxidase

• AMIGO entry for GO code 0050141: nitroethane oxidase