Nicotinate N-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a nicotinate N-methyltransferase (EC 2.1.1.7) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nicotinate S-adenosyl-L-homocysteine + N-methylnicotinate

Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinate, whereas its two products are S-adenosylhomocysteine and N-methylnicotinate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 5MHT.

[edit] References

• IUBMB entry for 2.1.1.7
• BRENDA references for 2.1.1.7 (Recommended.)
• PubMed references for 2.1.1.7
• PubMed Central references for 2.1.1.7
• Google Scholar references for 2.1.1.7
• Joshi JG and Handler P (1960). "Biosynthesis of trigonelline". J. Biol. Chem. 235: 2981–2983. 

[edit] External links

The CAS registry number for this enzyme class is 9029-79-2.

• IUBMB entry for 2.1.1.7

• KEGG entry for 2.1.1.7

• BRENDA entry for 2.1.1.7

• NiceZyme view of 2.1.1.7

• EC2PDB: PDB structures for 2.1.1.7

• PRIAM entry for 2.1.1.7

• PUMA2 entry for 2.1.1.7

• IntEnz: Integrated Enzyme entry for 2.1.1.7

• MetaCyc entry for 2.1.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008938: nicotinate N-methyltransferase

• AMIGO entry for GO code 0008938: nicotinate N-methyltransferase