Nicotinamide N-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nicotinamide S-adenosyl-L-homocysteine + 1-methylnicotinamide

Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinamide, whereas its two products are S-adenosylhomocysteine and 1-methylnicotinamide.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinamide N-methyltransferase. This enzyme is also called nicotinamide methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2I62 and 2IIP.

[edit] References

• IUBMB entry for 2.1.1.1
• BRENDA references for 2.1.1.1 (Recommended.)
• PubMed references for 2.1.1.1
• PubMed Central references for 2.1.1.1
• Google Scholar references for 2.1.1.1
• CANTONI GL (1951). "Methylation of nicotinamide with soluble enzyme system from rat liver". J. Biol. Chem. 189: 203–16. PMID 14832232. 

[edit] External links

The CAS registry number for this enzyme class is 9029-74-7.

• IUBMB entry for 2.1.1.1

• KEGG entry for 2.1.1.1

• BRENDA entry for 2.1.1.1

• NiceZyme view of 2.1.1.1

• EC2PDB: PDB structures for 2.1.1.1

• PRIAM entry for 2.1.1.1

• PUMA2 entry for 2.1.1.1

• IntEnz: Integrated Enzyme entry for 2.1.1.1

• MetaCyc entry for 2.1.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008112: nicotinamide N-methyltransferase

• AMIGO entry for GO code 0008112: nicotinamide N-methyltransferase