Nicotinamide-nucleotide amidase

From Wikipedia, the free encyclopedia

In enzymology, a nicotinamide-nucleotide amidase (EC 3.5.1.42) is an enzyme that catalyzes the chemical reaction

beta-nicotinamide D-ribonucleotide + H₂O beta-nicotinate D-ribonucleotide + NH₃

Thus, the two substrates of this enzyme are beta-nicotinamide D-ribonucleotide and H₂O, whereas its two products are beta-nicotinate D-ribonucleotide and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in common use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.

[edit] References

• IUBMB entry for 3.5.1.42
• BRENDA references for 3.5.1.42 (Recommended.)
• PubMed references for 3.5.1.42
• PubMed Central references for 3.5.1.42
• Google Scholar references for 3.5.1.42
• Imai T (Tokyo). "Purification and properties of nicotinamide mononucleotide amidohydrolase from Azotobacter vinelandii". J. Biochem.: 139–53. PMID 4144084. 

[edit] External links

The CAS registry number for this enzyme class is 37355-58-1.

• IUBMB entry for 3.5.1.42

• KEGG entry for 3.5.1.42

• BRENDA entry for 3.5.1.42

• NiceZyme view of 3.5.1.42

• EC2PDB: PDB structures for 3.5.1.42

• PRIAM entry for 3.5.1.42

• PUMA2 entry for 3.5.1.42

• IntEnz: Integrated Enzyme entry for 3.5.1.42

• MetaCyc entry for 3.5.1.42

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019159: nicotinamide-nucleotide amidase

• AMIGO entry for GO code 0019159: nicotinamide-nucleotide amidase