NGFRAP1

From Wikipedia, the free encyclopedia

Nerve growth factor receptor (TNFRSF16) associated protein 1

Identifiers

NGFRAP1; BEX3; Bex; DXS6984E; HGR74; NADE

External IDs

OMIM: 300361 MGI: 1338016 HomoloGene: 7642

Gene ontology
Molecular Function:	• molecular_function • death receptor binding • metal ion binding
Cellular Component:	• cellular_component • nucleus • cytosol
Biological Process:	• apoptosis • induction of apoptosis • multicellular organismal development • biological_process • induction of apoptosis via death domain receptors

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014380 (mRNA)
NP_055195 (protein)

XM_975991 (mRNA)
XP_981085 (protein)

Location

Chr X: 102.52 - 102.52 Mb

Chr X: 131.62 - 131.62 Mb

Pubmed search

[1]

[2]

Nerve growth factor receptor (TNFRSF16) associated protein 1, also known as NGFRAP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1.

[edit] Further reading

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Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. PMID 10514511.
Irie S, Hachiya T, Rabizadeh S, et al. (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.". FEBS Lett. 460 (2): 191–8. PMID 10544233.
Mukai J, Hachiya T, Shoji-Hoshino S, et al. (2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727.
Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways.". J. Neurochem. 76 (5): 1540–51. PMID 11238738.
Kimura MT, Irie S, Shoji-Hoshino S, et al. (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction.". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
Mukai J, Shoji S, Kimura MT, et al. (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tong X, Xie D, Roth W, et al. (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.". Int. J. Oncol. 22 (6): 1357–62. PMID 12739005.
Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis.". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats.". Gene 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yu Y, Wang J, Yuan H, et al. (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE.". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077.
Yasui S, Tsuzaki K, Ninomiya H, et al. (2007). "The TSC1 gene product hamartin interacts with NADE.". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.