NELL2

From Wikipedia, the free encyclopedia

NEL-like 2 (chicken)

Identifiers

External IDs

OMIM: 602320 MGI: 1858510 HomoloGene: 4488

Gene ontology
Molecular Function:	• structural molecule activity • calcium ion binding • protein binding
Cellular Component:	• extracellular region
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006159 (mRNA)
NP_006150 (protein)

NM_016743 (mRNA)
NP_058023 (protein)

Location

Chr 12: 43.19 - 43.56 Mb

Chr 15: 94.9 - 95.36 Mb

Pubmed search

[1]

[2]

NEL-like 2 (chicken), also known as NELL2, is a human gene.^[1]

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: NELL2 NEL-like 2 (chicken).

[edit] Further reading

Watanabe TK, Katagiri T, Suzuki M, et al. (1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.". Genomics 38 (3): 273–6. PMID 8975702.
Beckmann G, Hanke J, Bork P, Reich JG (1998). "Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins.". J. Mol. Biol. 275 (5): 725–30. doi:10.1006/jmbi.1997.1510. PMID 9480764.
Luce MJ, Burrows PD (1999). "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage.". Gene 231 (1-2): 121–6. PMID 10231576.
Kuroda S, Oyasu M, Kawakami M, et al. (1999). "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2.". Biochem. Biophys. Res. Commun. 265 (1): 79–86. doi:10.1006/bbrc.1999.1638. PMID 10548494.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.