NEK6

From Wikipedia, the free encyclopedia

NIMA (never in mitosis gene a)-related kinase 6

Identifiers

NEK6; SID6-1512

External IDs

OMIM: 604884 MGI: 1891638 HomoloGene: 49379

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein-tyrosine kinase activity • signal transducer activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • apoptosis • cell cycle • chromosome segregation • mitosis • regulation of mitotic metaphase/anaphase transition • positive regulation of I-kappaB kinase/NF-kappaB cascade • cell division

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_014397 (mRNA)
NP_055212 (protein)

NM_021606 (mRNA)
NP_067619 (protein)

Location

Chr 9: 126.06 - 126.16 Mb

n/a

Pubmed search

[1]

[2]

NIMA (never in mitosis gene a)-related kinase 6, also known as NEK6, is a human gene.^[1]

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6.

[edit] Further reading

Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.". Biochem. J. 339 ( Pt 2): 319–28. PMID 10191262.
Li MZ, Yu L, Liu Q, et al. (2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping.". Cytogenet. Cell Genet. 87 (3-4): 271–2. PMID 10702691.
Kandli M, Feige E, Chen A, et al. (2001). "Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA.". Genomics 68 (2): 187–96. doi:10.1006/geno.2000.6293. PMID 10964517.
Belham C, Comb MJ, Avruch J (2001). "Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.". Curr. Biol. 11 (15): 1155–67. PMID 11516946.
Kimura M, Okano Y (2001). "Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3.". Cytogenet. Cell Genet. 94 (1-2): 33–8. PMID 11701951.
Lizcano JM, Deak M, Morrice N, et al. (2002). "Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.". J. Biol. Chem. 277 (31): 27839–49. doi:10.1074/jbc.M202042200. PMID 12023960.
Hashimoto Y, Akita H, Hibino M, et al. (2002). "Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase.". Biochem. Biophys. Res. Commun. 293 (2): 753–8. doi:10.1016/S0006-291X(02)00297-8. PMID 12054534.
Roig J, Mikhailov A, Belham C, Avruch J (2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMID 12101123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Belham C, Roig J, Caldwell JA, et al. (2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
Yin MJ, Shao L, Voehringer D, et al. (2004). "The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.". J. Biol. Chem. 278 (52): 52454–60. doi:10.1074/jbc.M308080200. PMID 14563848.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chen J, Li L, Zhang Y, et al. (2006). "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.". Biochem. Biophys. Res. Commun. 341 (4): 1059–65. doi:10.1016/j.bbrc.2005.12.228. PMID 16476580.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Lee EJ, Hyun SH, Chun J, Kang SS (2007). "Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.". Biochem. Biophys. Res. Commun. 358 (3): 783–8. doi:10.1016/j.bbrc.2007.04.203. PMID 17512906.