NEK2

From Wikipedia, the free encyclopedia

NIMA (never in mitosis gene a)-related kinase 2

PDB rendering based on 2jav.

Available structures: 2jav

Identifiers

Symbol(s)

NEK2; HsPK 21; HsPK21; NEK2A; NLK1

External IDs

OMIM: 604043 MGI: 109359 HomoloGene: 74441

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• condensed nuclear chromosome • spindle pole • nucleus • centrosome • midbody
Biological Process:	• mitotic sister chromatid segregation • protein amino acid phosphorylation • cell cycle • regulation of mitosis • meiosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002497 (mRNA)
NP_002488 (protein)

NM_010892 (mRNA)
NP_035022 (protein)

Location

Chr 1: 209.9 - 209.92 Mb

Chr 1: 193.52 - 193.53 Mb

Pubmed search

[1]

[2]

NIMA (never in mitosis gene a)-related kinase 2, also known as NEK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2.

[edit] Further reading

Hayward DG, Fry AM (2006). "Nek2 kinase in chromosome instability and cancer.". Cancer Lett. 237 (2): 155–66. doi:10.1016/j.canlet.2005.06.017. PMID 16084011.
Schultz SJ, Fry AM, Sütterlin C, et al. (1994). "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.". Cell Growth Differ. 5 (6): 625–35. PMID 7522034.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Fry AM, Meraldi P, Nigg EA (1998). "A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.". EMBO J. 17 (2): 470–81. doi:10.1093/emboj/17.2.470. PMID 9430639.
Fry AM, Mayor T, Meraldi P, et al. (1998). "C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.". J. Cell Biol. 141 (7): 1563–74. PMID 9647649.
Fry AM, Arnaud L, Nigg EA (1999). "Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif.". J. Biol. Chem. 274 (23): 16304–10. PMID 10347187.
Schutte BC, Bjork BC, Coppage KB, et al. (2000). "A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41.". Genome Res. 10 (1): 81–94. PMID 10645953.
Helps NR, Luo X, Barker HM, Cohen PT (2001). "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.". Biochem. J. 349 (Pt 2): 509–18. PMID 10880350.
Hames RS, Fry AM (2002). "Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.". Biochem. J. 361 (Pt 1): 77–85. PMID 11742531.
Ha Kim Y, Yeol Choi J, Jeong Y, et al. (2002). "Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle.". Biochem. Biophys. Res. Commun. 290 (2): 730–6. doi:10.1006/bbrc.2001.6212. PMID 11785960.
Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
Chen Y, Riley DJ, Zheng L, et al. (2003). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.". J. Biol. Chem. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Faragher AJ, Fry AM (2004). "Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.". Mol. Biol. Cell 14 (7): 2876–89. doi:10.1091/mbc.E03-02-0108. PMID 12857871.
Lou Y, Yao J, Zereshki A, et al. (2004). "NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.". J. Biol. Chem. 279 (19): 20049–57. doi:10.1074/jbc.M314205200. PMID 14978040.
Noguchi K, Fukazawa H, Murakami Y, Uehara Y (2004). "Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.". J. Biol. Chem. 279 (31): 32716–27. doi:10.1074/jbc.M404104200. PMID 15161910.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
Lou Y, Xie W, Zhang DF, et al. (2004). "Nek2A specifies the centrosomal localization of Erk2.". Biochem. Biophys. Res. Commun. 321 (2): 495–501. doi:10.1016/j.bbrc.2004.06.171. PMID 15358203.