NDUFB7

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa

Identifiers

NDUFB7; B18; CI-B18; MGC2480

External IDs

OMIM: 603842 MGI: 1914166 HomoloGene: 3059

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity
Cellular Component:	• membrane fraction • mitochondrion • mitochondrial inner membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004146 (mRNA)
NP_004137 (protein)

XM_985698 (mRNA)
XP_990792 (protein)

Location

Chr 19: 14.54 - 14.54 Mb

Chr 8: 86.46 - 86.46 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa, also known as NDUFB7, is a human gene.^[1]

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.^[1]

[edit] References

^ ^a ^b Entrez Gene: NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa.

[edit] Further reading

Smeitink J, van den Heuvel L (1999). "Human mitochondrial complex I in health and disease.". Am. J. Hum. Genet. 64 (6): 1505-10. PMID 10330338.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Triepels R, Smeitink J, Loeffen J, et al. (2000). "Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients.". Hum. Genet. 106 (4): 385-91. PMID 10830904.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Emahazion T, Beskow A, Gyllensten U, Brookes AJ (1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain.". Cytogenet. Cell Genet. 82 (1-2): 115-9. PMID 9763677.
Wong YC, Tsao SW, Kakefuda M, Bernal SD (1990). "cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells.". Biochem. Biophys. Res. Commun. 166 (2): 984-92. PMID 2302251.