NDUFA10

From Wikipedia, the free encyclopedia

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa

Identifiers

NDUFA10; CI-42KD; MGC5103

External IDs

OMIM: 603835 MGI: 1914523 HomoloGene: 15342

Gene ontology
Molecular Function:	• NADH dehydrogenase activity • ATP binding • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity • phosphotransferase activity, alcohol group as acceptor
Cellular Component:	• membrane fraction • mitochondrion
Biological Process:	• generation of precursor metabolites and energy • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004544 (mRNA)
NP_004535 (protein)

NM_024197 (mRNA)
NP_077159 (protein)

Location

Chr 2: 240.55 - 240.61 Mb

Chr 1: 94.27 - 94.3 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa, also known as NDUFA10, is a human gene.^[1]

The protein encoded by this gene belongs to the complex I 42kDA subunit family. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.^[1]

[edit] References

^ ^a ^b Entrez Gene: NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa.

[edit] Further reading

Smeitink J, van den Heuvel L (1999). "Human mitochondrial complex I in health and disease.". Am. J. Hum. Genet. 64 (6): 1505-10. PMID 10330338.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63-72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415-22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Baens M, Chaffanet M, Aerssens J, et al. (1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids.". Genomics 21 (1): 296-7. doi:10.1006/geno.1994.1267. PMID 8088812.