NBR1

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Neighbor of BRCA1 gene 1
PDB rendering based on 1wj6.
Available structures: 1wj6, 2bkf, 2cp8, 2g4s
Identifiers
Symbol(s) NBR1; 1A1-3B; KIAA0049; M17S2; MIG19
External IDs OMIM: 166945 MGI: 108498 HomoloGene: 7438
Orthologs
Human Mouse
Entrez 4077 17966
Ensembl n/a ENSMUSG00000017119
Uniprot n/a Q05BC8
Refseq XM_001124650 (mRNA)
XP_001124650 (protein)		 NM_008676 (mRNA)
NP_032702 (protein)
Location n/a Chr 11: 101.37 - 101.4 Mb
Pubmed search [1] [2]

Neighbor of BRCA1 gene 1, also known as NBR1, is a human gene.[1]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: NBR1 neighbor of BRCA1 gene 1.

[edit] Further reading

  • Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.". Science 266 (5182): 66-71. PMID 7545954. 
  • Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene.". Hum. Mol. Genet. 4 (8): 1259-66. PMID 7581362. 
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223-9. PMID 7584044. 
  • Brown MA, Nicolai H, Xu CF, et al. (1995). "Regulation of BRCA1.". Nature 372 (6508): 733. doi:10.1038/372733a0. PMID 7997258. 
  • Campbell IG, Nicolai HM, Foulkes WD, et al. (1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.". Hum. Mol. Genet. 3 (4): 589-94. PMID 8069304. 
  • Brown MA, Xu CF, Nicolai H, et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21.". Oncogene 12 (12): 2507-13. PMID 8700509. 
  • Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes.". Gene 262 (1-2): 89-98. PMID 11179671. 
  • Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.". Eur. J. Biochem. 269 (2): 538-45. PMID 11856312. 
  • Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185-95. PMID 12107412. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.". J. Biol. Chem. 278 (36): 34568-81. doi:10.1074/jbc.M303221200. PMID 12813044. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover.". Science 308 (5728): 1599-603. doi:10.1126/science.1110463. PMID 15802564. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
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