Talk:NAPQI

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[edit] Mechanism for Metabolism

NAPQI in the mechanism diagram has he wrong structure. It should be a quinone not a phenol. The structure of the glutathioine conjugate product is also wrong. The reaction is a conjugate addition involving the removal of a double bond, not its addition. 87.127.28.229 (talk) 10:06, 30 December 2007 (UTC) Dr Adam Le Gresley

[edit] Acetylcysteine Side Effects

The article states that acetylcysteine can be given without risk of side effects.

This is inaccurate and is even contradicted in the main article for Acetylcysteine 82.47.1.14 (talk) 16:21, 24 March 2008 (UTC)

This page would be improved if the mechanism by which NAPQI destroy livers cells was explained. As a quinone, I would imagine that it has powerful oxidizing capability. Its detoxification by glutathione also supports that. However, I am only taking my best guess. Jon H. Connolly, Ph.D. —Preceding unsigned comment added by 24.206.157.172 (talk) 03:45, 29 April 2008 (UTC)