Naphthoate synthase

From Wikipedia, the free encyclopedia

In enzymology, a naphthoate synthase (EC 4.1.3.36) is an enzyme that catalyzes the chemical reaction

o-succinylbenzoyl-CoA $\rightleftharpoons$ CoA + 1,4-dihydroxy-2-naphthoate

Hence, this enzyme has one substrate, o-succinylbenzoyl-CoA, and two products, CoA and 1,4-dihydroxy-2-naphthoate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing CoA-forming). Other names in common use include 1,4-dihydroxy-2-naphthoate synthase, dihydroxynaphthoate synthase, and o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing). This enzyme participates in ubiquinone biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1Q51, 1Q52, 1RJM, 1RJN, and 2IEX.

[edit] References

IUBMB entry for 4.1.3.36
BRENDA references for 4.1.3.36 (Recommended.)
PubMed references for 4.1.3.36
PubMed Central references for 4.1.3.36
Google Scholar references for 4.1.3.36
Kolkmann R, Leistner E (1987). "4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis". Z. Naturforsch. [C]. 42: 1207–14. PMID 2966501.
Meganathan R, Bentley R (1979). "Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes". J. Bacteriol. 140: 92–8. PMID 500558.